Commonly Asked Questions – MTHFR Experts

If my homocysteine levels are high, how do I lower them?

High homocysteine levels, also known as hyperhomocysteinemia, are often linked to increased risks of cardiovascular disease, blood clots, and other health conditions.

To regulate healthy homocysteine levels, we recommend incorporating methylated B vitamins to support methylation, a critical process for maintaining balanced homocysteine. Key methylated B vitamins like methylfolate, methylB12, and B6 are essential for this function. Our Pure Methylation supplement provides these three vital B vitamins to help optimize homocysteine levels.

Additionally, TMG (Trimethylglycine) is a powerful tool for regulating homocysteine. Our Methylation3 supplement contains pure TMG, specifically designed to lower homocysteine levels effectively.

Both Pure Methylation and Methylation3 are available individually or together in our Regulate Homocysteine Combo for comprehensive support.

To lower high homocysteine levels, you can take the following steps:

1. Increase B vitamin intake through diet and supplements:

– Take folate (vitamin B9), vitamin B6, and vitamin B12 supplements[1][2][3].

– Eat more leafy green vegetables, fortified cereals, lentils, and beans for folate[3].

– Consume potatoes, bananas, chickpeas, and chicken for vitamin B6[3].

– Include dairy products, organ meats, beef, and certain fish for vitamin B12[3].

2. Adjust your diet:

– Reduce consumption of methionine-rich foods like red meat and dairy products[2].

– Eat at least five servings of fruits and vegetables daily[1].

– Include a clove of garlic daily or take a garlic supplement[1].

3. Make lifestyle changes:

– Exercise regularly[2].

– Reduce or eliminate alcohol consumption and smoking[2].

– Manage stress levels[1].

4. Consider additional supplements:

– Pure Methylation contains the 3 key B Vitamins needed to help get homocysteine levels healthy.

– N-acetylcysteine (NAC)[2][5].

– S-adenosylmethionine (SAMe)[2].

– Taurine[2].

5. Consult your doctor:

– They may recommend specific supplement dosages based on your homocysteine levels[3][5].

– Recheck your homocysteine levels after 8 weeks of supplementation[3].

Remember to consult with your healthcare provider before making significant changes to your diet or starting new supplements, especially if you’re taking medications[1][3].

Citations:

[1] https://foodforthebrain.org/cog-nition/seven-steps-to-keep-your-homocysteine-low/

[2] https://www.lifeextension.com/protocols/heart-circulatory/homocysteine-reduction

[3] https://familydoctor.org/high-homocysteine-level-how-it-affects-your-blood-vessels/

[4] https://www.health.harvard.edu/staying-healthy/In_brief_B_vitamins_and_homocysteine

[5] https://foodforthebrain.org/nutrition-for-healthcare-professionals/homocysteine-b-vitamins/

[6] https://www.ahajournals.org/doi/10.1161/01.cir.0000165142.37711.e7

If I have high levels of Estrogen, how do I reduce these levels?

To maintain healthy estrogen levels and address estrogen dominance, it’s important to focus on supporting methylation—a key process in estrogen metabolism. Supplementing with methylated B vitamins, such as methylfolate, methylB12, and B6, can enhance healthy methylation, which in turn promotes balanced estrogen levels.

Additionally, Calcium D-Glucarate is an excellent complement to methylated B vitamins. It aids in the safe elimination of excess estrogen from the body. Our Pure Methylation supplement contains essential B vitamins to support methylation and estrogen metabolism, while our Ca D-Glucarate Plus is specifically formulated to help reduce symptoms of estrogen dominance.

Both supplements are available individually or as a combination on our Combos page for optimal support.

To reduce high levels of estrogen, you can implement several dietary and lifestyle changes:

1. Modify your diet:

– Increase consumption of cruciferous vegetables like broccoli, cabbage, and Brussels sprouts[1][4].

– Add flaxseeds, which are high in lignans, to your meals[1][5].

– Incorporate fiber-rich foods such as whole grains, beans, and vegetables[1][4].

– Consume fatty fish like salmon and mackerel for omega-3 fatty acids[1][5].

– Include berries, green tea, and turmeric in your diet[1].

2. Make lifestyle adjustments:

– Exercise regularly to help regulate hormones and lower excess estrogen levels[7][8].

– Maintain a healthy weight, as excess body fat can increase estrogen production[3][8].

– Manage stress through activities like meditation and yoga[1].

– Ensure you get 7-9 hours of sleep per night[1].

3. Reduce exposure to environmental estrogens:

– Avoid using plastic containers for food and drink[1][7].

– Choose natural cleaning and personal care products[3].

– Opt for organic foods when possible to minimize exposure to pesticides[7].

4. Consider supplements:

– Consult with a healthcare professional about supplements like calcium-d-glucarate, indole-3-carbinol, or DIM (diindolylmethane)[1][6].

– Green tea extract (EGCG) may help balance estrogen levels[7].

5. Limit or avoid:

– Alcohol consumption[5][8].

– Processed and refined foods[8].

– Red meat and dairy products[1][8].

Remember to consult with a healthcare provider before making significant changes to your diet or starting any new supplements, especially if you have underlying health conditions or are taking medications.

Citations:

[1] https://www.medicinenet.com/what_foods_lower_decrease_flush_excess_estrogen/article.htm

[2] https://www.healthline.com/health/estrogen-blockers-for-men

[3] https://www.novaivffertility.com/fertility-help/high-estrogen-treatments-in-women

[4] https://www.va.gov/WHOLEHEALTHLIBRARY/tools/estrogen-dominance.asp

[5] https://www.medicalnewstoday.com/articles/323280

[6] https://citynaturopathic.ca/how-to-treat-estrogen-dominance/

[7] https://www.rupahealth.com/post/evidence-based-supplements-to-control-high-estrogen

[8] https://www.healthline.com/nutrition/foods-to-lower-estrogen

Tell me more about Detoxing and how it helps improve symptoms.

MTHFR mutations impair the body’s ability to methylate, a critical process required to remove certain toxins. When methylation is compromised, the body struggles to detoxify effectively, leading to the accumulation of toxins. These toxins remain in the body, causing inflammation and triggering symptoms associated with chronic inflammation.

Proper liver detoxification support is essential to help the body eliminate these accumulated toxins. By addressing the root cause of toxicity and reducing inflammation, you can relieve symptoms such as joint pain, fatigue, headaches, bloating, nausea, and skin conditions like inflammation-induced eczema.

Our Colon Cleanser/Liver Detox Program is designed to eliminate built-up toxins and fecal matter from the body. This comprehensive program not only alleviates inflammatory symptoms but also reduces inflammation, supports a healthy gut, and promotes balanced thyroid and hormone levels for overall well-being.

Detoxing can be particularly beneficial for individuals with MTHFR mutations, as these genetic variations can affect the body’s ability to process toxins efficiently. Here’s how detoxing helps improve symptoms of MTHFR:

## Enhancing Methylation

Detoxing supports the methylation process, which is crucial for individuals with MTHFR mutations:

– It helps increase levels of SAMe (S-adenosylmethionine), a key molecule for detoxification[1].

– Proper methylation supports phase II liver detoxification, making toxins water-soluble for easier elimination[6].

## Supporting Liver Function

The liver is the primary detox organ, and supporting its function is essential for MTHFR individuals:

– A detox protocol can help the liver filter toxins from the blood more effectively[6].

– It aids in converting harmful substances into forms that can be safely excreted[6].

## Reducing Toxic Load

MTHFR mutations can impair the body’s natural detoxification abilities, making it crucial to minimize toxin exposure:

– Detoxing helps reduce the overall toxic burden on the body[3].

– It supports the elimination of environmental toxins, which can be particularly problematic for those with MTHFR variations[1].

## Improving Gut Health

A healthy gut is essential for proper detoxification:

– Detoxing supports gut health, which plays a significant role in removing waste and preventing toxin reabsorption[6].

– A high-fiber diet during detox helps bind and remove toxins through the digestive tract[1].

## Boosting Overall Health

Detoxing can lead to various health improvements for MTHFR individuals:

– It supports the body’s natural detoxification processes, which may be compromised due to the mutation[1].

– Proper detoxification can help reduce inflammation and oxidative stress, common issues for those with MTHFR variations[3].

To effectively detox with MTHFR mutations, consider the following strategies:

1. Focus on natural folate sources rather than synthetic folic acid[1][3].

2. Support methylation with B-vitamins, especially B6, B12, and riboflavin[1].

3. Engage in gentle detox practices like proper hydration and moderate exercise[1].

4. Use infrared saunas or exercise to promote sweating and toxin elimination[2].

5. Supplement with glutathione to support detoxification[3].

6. Prioritize sleep and stress management to support overall detox pathways[6].

Remember to consult with a healthcare provider familiar with MTHFR mutations before starting any detox program, as individual needs may vary based on specific genetic variations and overall health status.

Citations:

[1] https://mthfrsupport.com.au/2023/12/detoxing-with-mthfr-variations-a-consumers-guide/

[2] https://methyl-life.com/blogs/mthfr-genetics/how-is-mthfr-treated-what-is-the-correct-sequence-of-supplements-to-treat-mthfr

[3] https://www.amymyersmd.com/blogs/articles/mthfr-mutation

[4] https://nikkiyeltonrd.com/mthfr-gene-mutation/

[5] https://mthfrstore.com/collections/detoxification

[6] https://www.purelyrootednutrition.com/post/supporting-detox-pathways-for-mthfr-gene-mutations

I have an MTHFR Mutation, what B Vitamins do I need?

If you have an MTHFR mutation, your body may struggle with effective methylation—a vital process responsible for critical functions like converting amino acids into proteins, processing homocysteine, and producing neurotransmitters. When methylation is impaired, these essential processes can be disrupted, leading to various health challenges.

To support healthy methylation, it’s crucial to incorporate methylated B vitamins into your routine. Vitamins like methylfolate, methylB12, and B6 serve as essential cofactors that facilitate methylation within the body. Supplementing with these key B vitamins can enhance your methylation process and alleviate symptoms associated with poor methylation.

Our Pure Methylation supplement is specifically formulated with the necessary methylated B vitamins to optimize support for individuals with MTHFR mutations. It provides these vitamins in the right forms and precise amounts tailored to your needs. Additionally, we offer targeted dosing recommendations based on your unique mutation to ensure your body receives the proper support for healthy methylation.

If you have an MTHFR mutation, you may benefit from taking specific forms of B vitamins that are more readily absorbed and utilized by your body. The key B vitamins to focus on are:

1. Methylfolate (L-5-MTHF): This is the active form of folate that bypasses the MTHFR enzyme deficiency[1][5]. It’s more bioavailable than folic acid for people with MTHFR mutations.

2. Active Vitamin B12: Methylcobalamin or hydroxocobalamin are preferred forms[1][4]. These are more easily absorbed and utilized by individuals with MTHFR mutations compared to cyanocobalamin.

3. Active Vitamin B6: Pyridoxal-5-Phosphate (P5P) is the active form of B6 that’s readily absorbed by the body[1].

4. Vitamin B2 (Riboflavin): This may be helpful, especially for those with the C677T mutation who also have high blood pressure[6].

It’s important to note that the specific needs can vary depending on the type of MTHFR mutation you have and your individual health status. Some people may benefit from a combination of these vitamins[4]. Always consult with a healthcare provider before starting any new supplement regimen, as they can help determine the appropriate dosages based on your specific needs and genetic profile[1][6].

Citations:

[1] https://www.xcode.life/mthfr-and-methylation/what-is-the-best-multivitamin-for-mthfr-mutation/

[2] https://www.seekinghealth.com/collections/dirty-genes-mthfr-support

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC4898281/

[4] https://methyl-life.com/blogs/b-12/mthfr-what-is-the-best-form-of-b12

[5] https://www.mygenefood.com/blog/do-mthfr-variants-affect-the-metabolism-of-all-b-vitamins/

[6] https://www.consumerlab.com/answers/how-does-a-mthfr-gene-mutation-affect-my-levels-of-b-vitamins/gene-mutation-b-vitamins/

[7] https://pubmed.ncbi.nlm.nih.gov/28689805/

[8] https://www.healthline.com/health/mthfr-gene

I have to have anesthesia done for a procedure, how can I best support my body before and after?

Start by informing your doctor about your MTHFR mutation so they can choose the most appropriate form of sedation tailored to your genetics. Individuals with MTHFR mutations may have difficulty with sedation due to challenges in methylation and detoxification processes.

To support healthy methylation and detoxification, consider adding a high-quality methylated B vitamin to your routine. We recommend BiomeIQ’s Pure Methylation, which can be taken before your procedure and continued afterward to maintain optimal support.

Additionally, it’s essential to focus on liver detoxification following procedures involving anesthesia to help your body efficiently eliminate toxins. For this, we recommend BiomeIQ’s Liver Detox Program, specifically designed to aid recovery and promote effective detoxification post-anesthesia.

To best support your body before and after anesthesia, consider the following recommendations:

Before anesthesia:

1. Follow pre-operative instructions carefully, especially regarding when to stop eating and drinking[2][6].

2. Stay hydrated by drinking water up until the allowed time, usually 2 hours before surgery[6].

3. Manage any existing health conditions, such as diabetes or high blood pressure, to ensure they’re well-controlled[5].

4. Maintain physical activity and exercise to improve your overall health and recovery[5].

5. Stop smoking and avoid alcohol for several days before surgery[5][6].

6. Attend pre-anesthesia screening appointments to discuss your medical history and any concerns[4].

7. Provide a complete list of medications, supplements, and allergies to your healthcare team[7].

8. Get any dental issues treated to reduce the risk of damage during intubation[5].

After anesthesia:

1. Arrange for a responsible adult to drive you home and stay with you for 24 hours after general anesthesia[7].

2. Follow post-operative instructions provided by your healthcare team.

3. Stay hydrated and eat light, easily digestible foods when allowed.

4. Rest and allow your body time to recover from the effects of anesthesia.

5. Report any unusual symptoms or side effects to your healthcare provider.

Remember to always consult with your anesthesiologist and surgical team for personalized advice based on your specific health condition and procedure[1][3].

Citations:

[1] https://www.webmd.com/a-to-z-guides/what-is-general-anesthesia

[2] https://www.webmd.com/pain-management/know-before-anesthesia

[3] https://www.mayoclinic.org/tests-procedures/anesthesia/about/pac-20384568

[4] https://www.mainehealth.org/care-services/anesthesiology-anesthesia/pre-anesthesia-screening

[5] https://www.nhs.uk/conditions/general-anaesthesia/

[6] https://mcpress.mayoclinic.org/living-well/what-to-do-and-avoid-before-anesthesia/

[7] https://www.medstarhealth.org/services/preparing-for-anesthesia

I’m pregnant, what can I do to help prepare my body for the healthiest pregnancy?

Many women with MTHFR mutations go on to have healthy pregnancies, but for some, these mutations can make it harder to conceive, increase the risk of complications during pregnancy, or lead to miscarriage. Consulting with a specialist who understands both pregnancy and MTHFR mutations can provide valuable guidance.

One key consideration is avoiding folic acid, as individuals with MTHFR mutations cannot metabolize it properly. Instead, opt for folate, which is a more bioavailable and effective form. Additionally, these mutations can make detoxification more challenging, so maintaining a clean and healthy lifestyle is essential. Minimizing exposure to environmental toxins such as processed foods, heavy metals, chemicals, and pesticides can help reduce toxin load and inflammation.

To support a healthy pregnancy, consider using a prenatal vitamin designed for optimal methylation support. BiomeIQ’s Baby B Mine is an excellent option, as it contains the ideal forms of essential vitamins, including methylated B vitamins to support methylation, choline for healthy brain development, and a bioavailable form of iron that’s gentle on the stomach. Adding a high-quality prenatal like this can be an important step in ensuring a healthy pregnancy for those with MTHFR mutations.

Congratulations on your pregnancy! To help prepare your body for the healthiest pregnancy possible, consider the following recommendations:

1. Take prenatal vitamins: Ensure you’re taking a daily prenatal vitamin containing at least 400 micrograms of folic acid to support your baby’s development and prevent neural tube defects[4][9].

2. Eat a balanced diet: Focus on consuming fresh fruits, vegetables, whole grains, lean proteins, and healthy fats. This will provide essential nutrients for you and your growing baby[2][3].

3. Stay hydrated: Aim to drink at least 8-10 glasses of water per day to maintain proper hydration[3].

4. Exercise regularly: Engage in moderate physical activity for about 30 minutes most days of the week, as approved by your healthcare provider[5].

5. Maintain a healthy weight: Work with your healthcare provider to ensure you’re gaining the appropriate amount of weight during pregnancy[1][3].

6. Avoid harmful substances: Stop smoking, drinking alcohol, and limit caffeine intake. Also, avoid exposure to toxic chemicals and radiation[3][8].

7. Get regular prenatal care: Schedule and attend all recommended prenatal check-ups with your healthcare provider[9].

8. Manage stress: Practice stress-reduction techniques such as meditation, yoga, or deep breathing exercises[1].

9. Get adequate sleep: Aim for 7-9 hours of quality sleep each night to support your body’s needs during pregnancy.

10. Avoid certain foods: Stay away from raw or undercooked meats, unpasteurized dairy products, and fish high in mercury[3].

Remember to consult with your healthcare provider for personalized advice based on your specific health needs and circumstances throughout your pregnancy.

Citations:

[1] https://www.centerfornaturaldeliveries.com/blog/7-tips-to-prepare-your-body-for-pregnancy

[2] https://www.rdwhc.com/blog/12-tips-for-preparing-your-body-for-pregnancy

[3] https://www.femmproobgyn.com/blog/10-tips-to-prepare-your-body-for-pregnancy

[4] https://www.marchofdimes.org/find-support/topics/planning-baby/getting-ready-pregnancy-preconception-health

[5] https://www.tommys.org/pregnancy-information/planning-a-pregnancy/how-to-get-pregnant/12-things-do-when-trying-baby

[6] https://www.lancastergeneralhealth.org/health-hub-home/motherhood/getting-pregnant/how-to-care-for-your-body-before-pregnancy

[7] https://www.healthline.com/health/pregnancy/how-to-prepare-your-body

[8] https://www.hopkinsmedicine.org/health/wellness-and-prevention/planning-a-pregnancy

[9] https://www.cdc.gov/pregnancy/about/index.html